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KMID : 0525720190240010033
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Journal of Chitin and Chitosan
2019 Volume.24 No. 1 p.33 ~ p.41
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Eliminatory Effect of Functional Drink Added with Several Medicinal Herb Complex Extracts on Ethanol-induced Blood Alcohol Concentration and Hangover in Rat
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Hwang Kwon-tack
Kim Jin-Seok
Kim Sun-Oh
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Abstract
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This study was performed to investigate the ameliorating effect of a hangover functional drink that contains medicinal herb complex extracts, on hepatoprotection and alcohol-metabolizing enzymes in ethanol-induced hangover in both in vitro and in vivo models. In human hepatoma cell line, HepG2, 300 mM of ethanol-induced hepatotoxicity was significantly improved by pretreatment of specific mixture of resources (SR). In the in vivo study, administration of ethanol to rats raised to the concentration of blood alcohol and lactate dehydrogenase (LDH). Blood alcohol concentrations and LDH levels in SR-treated rats significantly decreased at 0.5 h and 8 h after acute ethanol administration (40%, 4.6 g/kg body weight) as compared to ethanol-treated rats. Hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity were significantly higher in SR-treated rats than in ethanol-treated rats. These results suggest that SR exhibit hepatoprotective properties by enhancing ADH, ALDH activity in ethanol-induced hangover.
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KEYWORD
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Medicinal plant extracts, Alcohol, Hangover, Alcohol dehydrogenase (ADH), Aldehyde dehydrogenase (ALDH)
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